Beilstein J. Nanotechnol.2017,8, 1446–1456, doi:10.3762/bjnano.8.144
treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core–shell polymeric nanoparticles with positive charge by employing a chitosan coating. Additionally, an implantable formulation for the chemotherapeutic nanoparticles was developed as a bioadhesivefilm to be applied
: Docetaxel-loaded nanoparticles dispersed in a bioadhesivefilm were shown to be suitable for application of chemotherapeutics directly to the action site during surgical operation. The system was found to release chemotherapeutics for several days at the tumor site and neighboring tissue. This can be
suggested to result in a more effective brain tumor treatment when compared to chemotherapeutics administered as an intravenous bolus infusion.
Keywords: bioadhesivefilm; cationic nanoparticle; core–shell nanoparticle; docetaxel; glioma; Introduction
A brain tumor is known as an abnormal growth of
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Figure 1:
Particle size of blank and drug-loaded nanoparticles (n = 3, ± SD).